Strategies to prevent advanced liver inflammation associated with fatty liver disease
Fatty liver disease, driven by obesity, has become the most common liver disease worldwide. It's not just a nuisance for your liver function – it can lead to non-alcoholic fatty liver disease (NAFLD).
If left untreated, this condition could progress to liver inflammation due to metabolic dysfunction-associated steatohepatitis (MASH) and even liver cirrhosis. Fortunately, researchers at the German Cancer Research Institute have delved into the link between metabolic disorders and fatty liver, uncovering a simple dietary trick that not only eliminates liver fat but also conquers inflammation and reduces severe risks.
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Lowering liver inflammation is crucial. Researchers noticed that different types of intermittent fasting reduced liver inflammation. So they zeroed in on the 5:2 FAST, focusing on its mechanisms to better understand its benefits.
They compared mice who always had access to high-fat/high-sugar foods with mice who had only five days a week to scarf down those same tasty treats – with nothing the other two days. Surprisingly, even with a high-calorie diet, the intermittent fasting mice showed fewer signs of liver disease and had lower levels of biomarkers that indicate liver damage.
This resistance to liver disease happened even though the fasting mice ate just as many calories weekly as those who didn't fast, as they made up for the fasting periods with increased food intake. According to the researchers, the benefits came from the fact that fasting upped the levels of two molecular players – the transcription factor PPARα and the enzyme PCK1 – which work together to speed up fatty acid breakdown and gluconeogenesis while blocking fat buildup.
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Moving on, scientists tested the diet in mice that were already battling chronic liver inflammation due to a poor diet. Once again, the 5:2 intermittent fasting approach resulted in a roaring success. After four months, these mice had:
- Improved blood values
- Less fatty liver
- Reduced liver inflammation
- Lower rates of liver cancer and fewer cancer foci (microscopic cells) in the liver
"This demonstrates the immense potential of 5:2 intermittent fasting – both in preventing MASH and liver cancer, as well as in treating established chronic liver inflammation," said principal investigator, Mathias Heikenwälder.
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So, if you want to lower your chances of developing fatty liver disease, liver inflammation, and even liver cancer, intermittent fasting could be your answer. The 5:2 diet involves eating a healthy diet for five days and fasting on the remaining two days, or restricting intake on those fasting days to 500-600 calories for easier long-term adherence.
Support your liver further by:
- Consuming more protein - Studies have shown that adding more protein to your diet can help reduce liver fat.
- Intaking Resistant Starch - Participants who took a resistant starch supplement saw a 40 percent reduction in their liver triglyceride levels, as well as lower liver enzymes and inflammatory factors associated with NAFLD.
- Drinking Cocoa or Coffee - In one study, mice treated with cocoa had 28 percent less fat in their livers, while coffee consumption lowered liver enzymes and liver cancer risk.
- Enjoying Broccoli - It contains a compound that boosts the levels of a protein important for keeping NAFLD from advancing.
Liver problems can creep up on you. Watch out for these peculiar symptoms.
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Sources:
- Intermittent fasting protects against liver inflammation and liver cancer - EurekAlert!
- Fatty liver disease, driven by obesity, can progress to medical conditions like liver inflammation, non-alcoholic fatty liver disease (NAFLD), and even liver cirrhosis.
- Scientists have uncovered a simple dietary trick, intermittent fasting, that not only eliminates liver fat but also reduces inflammation and severe risks.
- The 5:2 FAST diet, a type of intermittent fasting, has been shown to reduce liver inflammation in various studies.
- Mice that followed the 5:2 intermittent fasting approach showed fewer signs of liver disease and had lower levels of biomarkers indicating liver damage.
- Due to the increased levels of PPARα and PCK1 during fasting periods, the fasting mice experienced improved fatty acid breakdown, gluconeogenesis, and reduced fat buildup.
- In mice with chronic liver inflammation due to a poor diet, the 5:2 intermittent fasting approach resulted in improved blood values, less fatty liver, reduced liver inflammation, lower rates of liver cancer, and fewer cancer foci in the liver.
- Intermittent fasting, particularly the 5:2 diet, could be beneficial for lowering liver inflammation and even liver cancer risk.
- Besides intermittent fasting, consuming more protein, taking resistant starch supplements, drinking cocoa or coffee, and eating broccoli can help reduce liver problems associated with NAFLD.
- Unusual symptoms may indicate liver problems, so it is essential to pay attention to them.
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