Side Effects of Xospata: Ranging from Mild to Severe, Recommendations for Management
Xospata, a targeted therapy for FLT3-mutated Acute Myeloid Leukemia (AML), has been approved by the Food and Drug Administration (FDA) since 2018. This medication, whose active ingredient is gilteritinib, is taken in the form of oral tablets and is crucial for treating certain adults with AML.
While Xospata has shown effectiveness in managing AML, it is essential to be aware of its potential side effects, particularly those that may arise during long-term treatment. Common long-term side effects include fatigue, nausea, diarrhea, constipation, muscle or joint pain, elevated liver enzymes, edema (swelling), breathlessness, increased transaminase levels, headache, dizziness, vomiting, renal impairment, hypotension (low blood pressure), fever, rash, and cough [1].
One serious but less common side effect is Differentiation Syndrome, a condition related to abnormal blood cell behavior that can cause fever, breathing difficulties, low blood pressure, kidney damage, and severe fluid buildup. This usually occurs within the first few weeks of treatment but is important to be aware of long-term [3].
Regular monitoring of liver and kidney function is critical during treatment to manage these risks. Xospata's side effects reflect its mechanism and impact on blood and organs [1][2].
If side effects from Xospata occur, they can be treated by the doctor's recommendation. For instance, if nausea occurs, the doctor may recommend ginger candies, ginger ale, or a nausea medication. Pregnancy and breastfeeding are not safe while taking Xospata, and pregnancy tests and birth control will be recommended before and during treatment [1].
It's also important to note that Xospata does not typically cause hair loss. However, it can cause an allergic reaction in some people, with symptoms including skin rash, itching, flushing, swelling under the skin, swelling of the mouth, tongue, or throat, and other symptoms. For mild symptoms of an allergic reaction, call the doctor right away. For serious symptoms, immediately call 911 or your local emergency number [1].
In conclusion, while Xospata offers a valuable treatment option for certain AML patients, it is essential to be aware of its potential long-term side effects and to undergo regular medical monitoring to manage these risks during extended treatment periods. If symptoms of Differentiation Syndrome occur, it's important to tell the doctor or go to the hospital right away to get immediate treatment.
- Xospata, a medical-condition-targeted therapy for FLT3-mutated Acute Myeloid Leukemia (AML), may cause several side effects during long-term treatment, such as fatigue, nausea, and increased transaminase levels, among others.
- One serious but less common side effect of Xospata is Differentiation Syndrome, a medical-condition related to abnormal blood cell behavior that can cause severe symptoms like fever, breathing difficulties, and kidney damage.
- While Xospata's side effects reflect its impact on blood and organs, they can be managed through various health-and-wellness therapies and treatments when recommended by a doctor.
- It's crucial for individuals taking Xospata to be aware that pregnancy and breastfeeding are not safe, and pregnancy tests and birth control will be recommended before and during treatment to prevent associated risks.
