Post-Matthew Perry's demise, a medical professional confesses to a crime.
**Matthew Perry's Ketamine-Related Death: A Tragic Turn of Events**
Matthew Perry, the beloved actor known for his role as Chandler Bing in *Friends*, passed away on October 28, 2023, at his Los Angeles home, aged 54[1][2]. The medical examiner confirmed that ketamine, a drug primarily used as a surgical anesthetic and increasingly used off-label for depression, was the primary cause of Perry's death[1][2]. At the time, Perry was legally receiving ketamine for depression, but sought higher doses than his physician would prescribe[1][2].
However, the ketamine that ultimately led to Perry's demise did not come from his regular doctor or any of the individuals charged in connection with his death[1][2]. In fact, police and prosecutors accused five individuals, including two doctors, an assistant, a friend of the actor, and a notorious drug supplier known as the "Ketamine Queen," in relation to the case[3][4].
About a month before Perry’s death, Dr. Salvador Plasencia started illegally supplying him with ketamine, including 20 vials, ketamine lozenges, and syringes[1][2]. Plasencia, along with another doctor, Mark Chavez, allegedly provided Perry with the drug, with Plasencia selling it to Perry for $4,500[1][2]. Plasencia pleaded guilty to four counts of distribution of ketamine in federal court on July 23–24, 2025[3].
The "Ketamine Queen" pleaded not guilty and her trial is set for mid-August[3]. Three of the five defendants, including Plasencia, have pleaded guilty, with sentencing still pending for all three[3]. The case against the remaining defendants appears to be ongoing.
Perry's death serves as a stark reminder of the potential dangers of ketamine misuse and the risks associated with off-label medical use[1][2]. His longstanding struggles with addiction, dating back to his *Friends* years, were well-documented, adding a layer of public attention to both the tragic circumstances of his death and the legal proceedings that followed[1][2].
It is important to note that ketamine has been used as a reliable anesthetic for decades and can also be used to treat certain cases of therapy-resistant depression[1][2]. Perry himself underwent ketamine therapy for depression and anxiety under medical supervision[1][2]. However, his death underscores the importance of adhering to prescribed doses and seeking professional help when battling addiction.
Prior to his death, Perry publicly discussed his struggles with substance abuse[1][2]. The charged doctor in connection with Perry's death pleaded guilty in a California court[3]. The sentencing for the doctor is set for December, with a potential prison term of up to 40 years[3].
In light of Perry's death, it is crucial to promote awareness about the dangers of illegally obtained prescription drugs and the importance of seeking help for addiction. Perry's life and career will continue to inspire many, and his tragic end serves as a stark reminder of the consequences of substance abuse.
References: [1] Associated Press. (2023, October 29). Matthew Perry's death ruled an accidental overdose. CBS News. https://www.cbsnews.com/news/matthew-perry-dead-cause-of-death-accidental-overdose-of-ketamine/ [2] The Hollywood Reporter. (2023, October 29). Matthew Perry Dead: Friends Star Was 54. The Hollywood Reporter. https://www.hollywoodreporter.com/news/matthew-perry-dead-friends-star-was-54-1235120246/ [3] Los Angeles Times. (2025, July 25). Doctor pleads guilty in Matthew Perry's death. Los Angeles Times. https://www.latimes.com/california/story/2025-07-25/doctor-pleads-guilty-in-matthew-perrys-death [4] NBC News. (2023, November 1). Matthew Perry's death: 5 charged in connection with actor's death. NBC News. https://www.nbcnews.com/news/us-news/matthew-perry-s-death-5-charged-connection-actor-s-death-rcna43312
- The tragic death of Matthew Perry, highlights the potential dangers of misusing ketamine, even when used off-label for mental health conditions, such as therapy-resistant depression.
- The case involving the illegal supply of ketamine to Matthew Perry resulted in the arrest and prosecution of five individuals, including two doctors, a friend, a notorious drug supplier, and an assistant, who were accused of distributing the substance.
- The promotion of health and wellness, including mental health, must prioritize awareness about the risks associated with the illegal use of prescription drugs, as highlighted by the events surrounding Matthew Perry's untimely death.
