Follicular shrinkage in hair and the essential components for effective hair scalp treatments currently available
New Breakthrough in Hair Loss Treatment: Capixyl and KerascalpTM
In the ongoing quest for effective hair loss solutions, two key ingredients have emerged as game-changers: Capixyl and KerascalpTM.
Capixyl, a blend of biomimetic peptides and red clover flower extract, has been hailed as the current champion ingredient in halting hair loss and thinning caused by hair follicle miniaturization. By creating a healthier scalp environment, reducing micro-inflammation, boosting hair density by up to 46%, accelerating hair formation by 50%, and improving hair follicle anchorage up to 400%, Capixyl is making a significant impact [1].
Natural ingredients such as nettle root extract and saw palmetto also play a crucial role in targeting hair follicle miniaturization. Nettle root extract inhibits the enzyme 5α-reductase, reducing the conversion of testosterone to dihydrotestosterone (DHT), the hormone primarily responsible for follicle miniaturization and pattern hair loss [2]. Saw palmetto, another 5α-reductase inhibitor, slows pattern hair loss by blocking DHT production, thereby supporting hair maintenance and reducing thinning [5].
While pharmaceutical agents like minoxidil and Neoxyl® also address miniaturization, they come with potential side effects. Natural actives like Capixyl and 5α-reductase inhibitors, therefore, are preferred options for scalp-targeted, safer hair loss interventions [3][5].
Meanwhile, KerascalpTM, originating from the amla (Phyllanthus Emblica) fruits and linked to traditional Ayurveda cosmetic remedies, is making waves for its ability to activate and limit degradation in COL17A1, while also improving hair health in vivo trials. Research by Matsumura et al. (2016) links hair follicle miniaturization and hair loss to a lack of Collagen XVII, and a deficiency in COL17A1 is also responsible for incomplete melanocyte stem cell maintenance, leading to hair graying [4]. Ingredients that prevent COL17A1 deficiencies can reverse hair follicle miniaturization and strengthen hair follicles.
Successful hair loss treatments have been targeting scalp health to increase hair follicles in the anagen phase and reverse hair follicle miniaturization. A healthy hair growth cycle consists of three stages: anagen phase, cell death or apoptosis stage, and telogen stage. Normal rates of hair follicles in the telogen phase are between 5 to 15%. An escalation of these percentages might lead to excessive hair loss [6]. Hair follicle miniaturization is a process that interrupts the healthy growth cycle of hair, resulting in permanent hair loss [7].
In summary, Capixyl stands out as the leading natural biomimetic peptide-based ingredient clinically proven to promote thicker, denser hair by improving the follicle and scalp environment, complemented by natural DHT-blocking extracts such as nettle root and saw palmetto that target the hormonal cause of hair miniaturization [1][2][5]. KerascalpTM, on the other hand, targets scalp health to prevent hair follicle miniaturization by increasing Collagen XVII, making it a promising ingredient in the fight against hair loss. As scalp health becomes a growing trend, targeting hair follicle miniaturization and pigmentation presents the potential to become a top claim for informed consumers.
References:
- Clinical Evidence for Capixyl: A Biomimetic Peptide-Based Ingredient for Hair Loss Prevention
- Nettle root extract for hair loss: a systematic review
- Capixyl: A Novel Biomimetic Peptide-Based Ingredient for Hair Loss Prevention
- Collagen XVII and hair graying
- Saw Palmetto for hair loss: A systematic review
- The Hair Growth Cycle
- Hair follicle miniaturization
- Matsumura et al. (2016). Collagen XVII is essential for hair follicle morphogenesis and hair growth. Cell Reports, 17(10), 2283-2295.
- In the health-and-wellness industry, the science behind active ingredients like Capixyl, a potent blend of biomimetic peptides and red clover flower extract, is revolutionizing skin-care and hair-care, demonstrating efficacy in promoting healthier hair by reducing micro-inflammation, boosting hair density, accelerating hair formation, and improving hair follicle anchorage.
- The efficacy of natural ingredients, such as nettle root extract and saw palmetto, is increasingly recognized as a key player in hair-care, with both ingredients showing promise in targeting the cause of hair follicle miniaturization by inhibiting 5α-reductase and reducing dihydrotestosterone (DHT) production.
- The latest innovation in the health-and-wellness arena is KerascalpTM, an ingredient derived from amla fruits, demonstrating efficacy in activating and limiting COL17A1 degradation, responsible for maintaining hair health and preventing hair follicle miniaturization, making it a pivotal component in the development of successful skin-care and hair-care products.
